diff --git a/litellm/llms/bedrock/chat/invoke_transformations/anthropic_claude3_transformation.py b/litellm/llms/bedrock/chat/invoke_transformations/anthropic_claude3_transformation.py
index f003c0ed95..53e0822979 100644
--- a/litellm/llms/bedrock/chat/invoke_transformations/anthropic_claude3_transformation.py
+++ b/litellm/llms/bedrock/chat/invoke_transformations/anthropic_claude3_transformation.py
@@ -103,7 +103,7 @@ class AmazonAnthropicClaudeConfig(AmazonInvokeConfig, AnthropicConfig):
             model=model,
             optional_params=optional_params,
             computer_tool_used=self.is_computer_tool_used(tools),
-            prompt_caching_set=self.is_cache_control_set(messages),
+            prompt_caching_set=False, 
             file_id_used=self.is_file_id_used(messages),
             mcp_server_used=self.is_mcp_server_used(optional_params.get("mcp_servers")),
         )
diff --git a/litellm/llms/bedrock/messages/invoke_transformations/anthropic_claude3_transformation.py b/litellm/llms/bedrock/messages/invoke_transformations/anthropic_claude3_transformation.py
index aea8a4b5a8..32be1a780a 100644
--- a/litellm/llms/bedrock/messages/invoke_transformations/anthropic_claude3_transformation.py
+++ b/litellm/llms/bedrock/messages/invoke_transformations/anthropic_claude3_transformation.py
@@ -157,7 +157,7 @@ class AmazonAnthropicClaudeMessagesConfig(
             model=model,
             optional_params=anthropic_messages_optional_request_params,
             computer_tool_used=anthropic_model_info.is_computer_tool_used(tools),
-            prompt_caching_set=anthropic_model_info.is_cache_control_set(messages_typed),
+            prompt_caching_set=False,
             file_id_used=anthropic_model_info.is_file_id_used(messages_typed),
             mcp_server_used=anthropic_model_info.is_mcp_server_used(
                 anthropic_messages_optional_request_params.get("mcp_servers")
diff --git a/tests/test_litellm/llms/bedrock/test_anthropic_beta_support.py b/tests/test_litellm/llms/bedrock/test_anthropic_beta_support.py
index 1b9e1b5284..bd64670517 100644
--- a/tests/test_litellm/llms/bedrock/test_anthropic_beta_support.py
+++ b/tests/test_litellm/llms/bedrock/test_anthropic_beta_support.py
@@ -5,14 +5,19 @@ Tests that anthropic-beta headers are correctly processed and passed to AWS Bedr
 for enabling beta features like 1M context window, computer use tools, etc.
 """
 
-import pytest
-from unittest.mock import patch, MagicMock
 import json
+from unittest.mock import MagicMock, patch
+
+import pytest
 
-from litellm.llms.bedrock.common_utils import get_anthropic_beta_from_headers
 from litellm.llms.bedrock.chat.converse_transformation import AmazonConverseConfig
-from litellm.llms.bedrock.chat.invoke_transformations.anthropic_claude3_transformation import AmazonAnthropicClaudeConfig
-from litellm.llms.bedrock.messages.invoke_transformations.anthropic_claude3_transformation import AmazonAnthropicClaudeMessagesConfig
+from litellm.llms.bedrock.chat.invoke_transformations.anthropic_claude3_transformation import (
+    AmazonAnthropicClaudeConfig,
+)
+from litellm.llms.bedrock.common_utils import get_anthropic_beta_from_headers
+from litellm.llms.bedrock.messages.invoke_transformations.anthropic_claude3_transformation import (
+    AmazonAnthropicClaudeMessagesConfig,
+)
 
 
 class TestAnthropicBetaHeaderSupport:
@@ -56,7 +61,8 @@ class TestAnthropicBetaHeaderSupport:
         )
         
         assert "anthropic_beta" in result
-        assert result["anthropic_beta"] == ["context-1m-2025-08-07", "computer-use-2024-10-22"]
+        # Beta flags are stored as sets, so order may vary
+        assert set(result["anthropic_beta"]) == {"context-1m-2025-08-07", "computer-use-2024-10-22"}
 
     def test_converse_transformation_anthropic_beta(self):
         """Test that Converse API transformation includes anthropic_beta in additionalModelRequestFields."""
@@ -163,4 +169,122 @@ class TestAnthropicBetaHeaderSupport:
         )
         
         assert "anthropic_beta" in result
-        assert result["anthropic_beta"] == supported_features
\ No newline at end of file
+        # Beta flags are stored as sets, so order may vary
+        assert set(result["anthropic_beta"]) == set(supported_features)
+
+    def test_prompt_caching_no_beta_header_messages_api(self):
+        """Test that prompt caching (cache_control) does NOT add prompt-caching-2024-07-31 beta header for Bedrock.
+        
+        Bedrock recognizes prompt caching via the request body (cache_control field),
+        not through beta headers. This test verifies the fix.
+        """
+        config = AmazonAnthropicClaudeMessagesConfig()
+        headers = {}
+        
+        # Messages with cache_control set (prompt caching enabled)
+        messages = [
+            {
+                "role": "user",
+                "content": [
+                    {
+                        "type": "text",
+                        "text": "Hello",
+                        "cache_control": {"type": "ephemeral"}
+                    }
+                ]
+            }
+        ]
+        
+        result = config.transform_anthropic_messages_request(
+            model="us.anthropic.claude-sonnet-4-5-20250929-v1:0",
+            messages=messages,
+            anthropic_messages_optional_request_params={"max_tokens": 100},
+            litellm_params={},
+            headers=headers
+        )
+        
+        # Verify prompt-caching-2024-07-31 is NOT in anthropic_beta
+        if "anthropic_beta" in result:
+            assert "prompt-caching-2024-07-31" not in result["anthropic_beta"], (
+                "prompt-caching-2024-07-31 should not be added as a beta header for Bedrock. "
+                "Bedrock recognizes prompt caching via cache_control in the request body, not beta headers."
+            )
+        else:
+            # It's also valid if anthropic_beta is not present at all
+            assert True
+
+    def test_prompt_caching_no_beta_header_chat_api(self):
+        """Test that prompt caching (cache_control) does NOT add prompt-caching-2024-07-31 beta header for Bedrock Chat API.
+        
+        Bedrock recognizes prompt caching via the request body (cache_control field),
+        not through beta headers. This test verifies the fix.
+        """
+        config = AmazonAnthropicClaudeConfig()
+        headers = {}
+        
+        # Messages with cache_control set (prompt caching enabled)
+        messages = [
+            {
+                "role": "user",
+                "content": [
+                    {
+                        "type": "text",
+                        "text": "Hello",
+                        "cache_control": {"type": "ephemeral"}
+                    }
+                ]
+            }
+        ]
+        
+        result = config.transform_request(
+            model="us.anthropic.claude-sonnet-4-5-20250929-v1:0",
+            messages=messages,
+            optional_params={},
+            litellm_params={},
+            headers=headers
+        )
+        
+        # Verify prompt-caching-2024-07-31 is NOT in anthropic_beta
+        if "anthropic_beta" in result:
+            assert "prompt-caching-2024-07-31" not in result["anthropic_beta"], (
+                "prompt-caching-2024-07-31 should not be added as a beta header for Bedrock. "
+                "Bedrock recognizes prompt caching via cache_control in the request body, not beta headers."
+            )
+        else:
+            # It's also valid if anthropic_beta is not present at all
+            assert True
+
+    def test_prompt_caching_with_other_beta_headers(self):
+        """Test that prompt caching doesn't interfere with other valid beta headers."""
+        config = AmazonAnthropicClaudeMessagesConfig()
+        headers = {"anthropic-beta": "context-1m-2025-08-07"}
+        
+        # Messages with cache_control set
+        messages = [
+            {
+                "role": "user",
+                "content": [
+                    {
+                        "type": "text",
+                        "text": "Hello",
+                        "cache_control": {"type": "ephemeral"}
+                    }
+                ]
+            }
+        ]
+        
+        result = config.transform_anthropic_messages_request(
+            model="us.anthropic.claude-sonnet-4-5-20250929-v1:0",
+            messages=messages,
+            anthropic_messages_optional_request_params={"max_tokens": 100},
+            litellm_params={},
+            headers=headers
+        )
+        
+        # Should have the user-provided beta header but NOT prompt-caching
+        if "anthropic_beta" in result:
+            assert "context-1m-2025-08-07" in result["anthropic_beta"]
+            assert "prompt-caching-2024-07-31" not in result["anthropic_beta"]
+        else:
+            # If no beta headers, that's also fine
+            assert True
\ No newline at end of file