diff --git a/litellm/caching/llm_caching_handler.py b/litellm/caching/llm_caching_handler.py
index 16eb824f4c..331aa8f51c 100644
--- a/litellm/caching/llm_caching_handler.py
+++ b/litellm/caching/llm_caching_handler.py
@@ -3,11 +3,37 @@ Add the event loop to the cache key, to prevent event loop closed errors.
 """
 
 import asyncio
+from typing import Set
 
 from .in_memory_cache import InMemoryCache
 
 
 class LLMClientCache(InMemoryCache):
+    # Background tasks must be stored to prevent garbage collection, which would
+    # trigger "coroutine was never awaited" warnings. See:
+    # https://docs.python.org/3/library/asyncio-task.html#creating-tasks
+    # Intentionally shared across all instances as a global task registry.
+    _background_tasks: Set[asyncio.Task] = set()
+
+    def _remove_key(self, key: str) -> None:
+        """Close async clients before evicting them to prevent connection pool leaks."""
+        value = self.cache_dict.get(key)
+        super()._remove_key(key)
+        if value is not None:
+            close_fn = getattr(value, "aclose", None) or getattr(value, "close", None)
+            if close_fn and asyncio.iscoroutinefunction(close_fn):
+                try:
+                    task = asyncio.get_running_loop().create_task(close_fn())
+                    self._background_tasks.add(task)
+                    task.add_done_callback(self._background_tasks.discard)
+                except RuntimeError:
+                    pass
+            elif close_fn and callable(close_fn):
+                try:
+                    close_fn()
+                except Exception:
+                    pass
+
     def update_cache_key_with_event_loop(self, key):
         """
         Add the event loop to the cache key, to prevent event loop closed errors.
diff --git a/tests/test_litellm/caching/test_llm_caching_handler.py b/tests/test_litellm/caching/test_llm_caching_handler.py
new file mode 100644
index 0000000000..0ac4ac5de7
--- /dev/null
+++ b/tests/test_litellm/caching/test_llm_caching_handler.py
@@ -0,0 +1,158 @@
+import asyncio
+import os
+import sys
+import warnings
+
+import pytest
+
+sys.path.insert(
+    0, os.path.abspath("../../..")
+)  # Adds the parent directory to the system path
+
+from litellm.caching.llm_caching_handler import LLMClientCache
+
+
+class MockAsyncClient:
+    """Mock async HTTP client with an async close method."""
+
+    def __init__(self):
+        self.closed = False
+
+    async def close(self):
+        self.closed = True
+
+
+class MockSyncClient:
+    """Mock sync HTTP client with a sync close method."""
+
+    def __init__(self):
+        self.closed = False
+
+    def close(self):
+        self.closed = True
+
+
+@pytest.mark.asyncio
+async def test_remove_key_no_unawaited_coroutine_warning():
+    """
+    Test that evicting an async client from LLMClientCache does not produce
+    'coroutine was never awaited' warnings.
+
+    Regression test for https://github.com/BerriAI/litellm/issues/22128
+    """
+    cache = LLMClientCache(max_size_in_memory=2)
+
+    mock_client = MockAsyncClient()
+    cache.cache_dict["test-key"] = mock_client
+    cache.ttl_dict["test-key"] = 0  # expired
+
+    with warnings.catch_warnings(record=True) as caught_warnings:
+        warnings.simplefilter("always")
+        cache._remove_key("test-key")
+        # Let the event loop process the close task
+        await asyncio.sleep(0.1)
+
+    coroutine_warnings = [
+        w for w in caught_warnings if "coroutine" in str(w.message).lower()
+    ]
+    assert (
+        len(coroutine_warnings) == 0
+    ), f"Got unawaited coroutine warnings: {coroutine_warnings}"
+
+
+@pytest.mark.asyncio
+async def test_remove_key_closes_async_client():
+    """
+    Test that evicting an async client from the cache properly closes it.
+    """
+    cache = LLMClientCache(max_size_in_memory=2)
+
+    mock_client = MockAsyncClient()
+    cache.cache_dict["test-key"] = mock_client
+    cache.ttl_dict["test-key"] = 0
+
+    cache._remove_key("test-key")
+    # Let the event loop process the close task
+    await asyncio.sleep(0.1)
+
+    assert mock_client.closed is True
+    assert "test-key" not in cache.cache_dict
+    assert "test-key" not in cache.ttl_dict
+
+
+def test_remove_key_closes_sync_client():
+    """
+    Test that evicting a sync client from the cache properly closes it.
+    """
+    cache = LLMClientCache(max_size_in_memory=2)
+
+    mock_client = MockSyncClient()
+    cache.cache_dict["test-key"] = mock_client
+    cache.ttl_dict["test-key"] = 0
+
+    cache._remove_key("test-key")
+
+    assert mock_client.closed is True
+    assert "test-key" not in cache.cache_dict
+
+
+@pytest.mark.asyncio
+async def test_eviction_closes_async_clients():
+    """
+    Test that cache eviction (when cache is full) properly closes async clients
+    without producing warnings.
+    """
+    cache = LLMClientCache(max_size_in_memory=2, default_ttl=1)
+
+    clients = []
+    for i in range(2):
+        client = MockAsyncClient()
+        clients.append(client)
+        cache.set_cache(f"key-{i}", client)
+
+    with warnings.catch_warnings(record=True) as caught_warnings:
+        warnings.simplefilter("always")
+        # This should trigger eviction of one of the existing entries
+        cache.set_cache("key-new", "new-value")
+        await asyncio.sleep(0.1)
+
+    coroutine_warnings = [
+        w for w in caught_warnings if "coroutine" in str(w.message).lower()
+    ]
+    assert (
+        len(coroutine_warnings) == 0
+    ), f"Got unawaited coroutine warnings: {coroutine_warnings}"
+
+
+def test_remove_key_no_event_loop():
+    """
+    Test that _remove_key doesn't raise when there's no running event loop
+    (falls through to the RuntimeError except branch).
+    """
+    cache = LLMClientCache(max_size_in_memory=2)
+
+    mock_client = MockAsyncClient()
+    cache.cache_dict["test-key"] = mock_client
+    cache.ttl_dict["test-key"] = 0
+
+    # Should not raise even though there's no running event loop
+    cache._remove_key("test-key")
+    assert "test-key" not in cache.cache_dict
+
+
+@pytest.mark.asyncio
+async def test_background_tasks_cleaned_up_after_completion():
+    """
+    Test that completed close tasks are removed from the _background_tasks set.
+    """
+    cache = LLMClientCache(max_size_in_memory=2)
+
+    mock_client = MockAsyncClient()
+    cache.cache_dict["test-key"] = mock_client
+    cache.ttl_dict["test-key"] = 0
+
+    cache._remove_key("test-key")
+    # Let the task complete
+    await asyncio.sleep(0.1)
+
+    assert len(cache._background_tasks) == 0